Publications
Multimodal spatial profiling reveals immune suppression and microenvironment remodeling in fallopian tube precursors to high-grade serous ovarian carcinoma
Kader T, Lin J-R, Hug C, Coy S, Chen Y-A, de Bruijn I, Shih N, Jung, E, ... Santagata S
Cancer Discovery. 2024 Dec 20. https://doi.org/10.1158/2159-8290.CD-24-1366
PMCID: 39704522
Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.
Williams MJ, Oliphant MUJ, Au V, Liu C, Baril C, O’Flanagan C, Lai D, Beatty S, ... Aparicio, S.
Nature Genetics. 2024 Nov 20; 56(12), 2753–2762. https://doi.org/10.1038/s41588-024-01988-0
PMCID: PMC11631757
Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer
Li CM, Cordes A, Oliphant MUJ, Quinn SA, Thomas M, Selfors LM, Silvestri F, Girnius N, ... Brugge JS.
Nature Genetics. 2024 Nov 11; 56(12):2763-277 https://doi.org/10.1038/s41588-024-01958-6
A human breast atlas integrating single-cell proteomics and transcriptomics.
Gray GK, Li CM-C, Rosenbluth JM, Selfors LM, Girnius N, Lin J-R, Schackmann RCJ, Goh WL, ... Brugge JS.
Developmental Cell. 2022 Jun 6; 57(11):1400-1420.e7. https://doi.org/10.1016/j.devcel.2022.05.003
PMCID: PMC9202341
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
Ferrari AJ, Rawat P, Rendulich HS, Annapragada AV, Kinose Y, Zhang X, Devins K, Budina A, ... Drapkin R.
JCI Insight. 2023 Jun 22;8(12):e164995. https://doi.org/10.1172/jci.insight.164995
PMCID: PMC10371241
Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers.
Karaayvaz-Yildirim M, Silberman RE, Langenbucher A, Saladi SV, Ross KN, Zarcaro E, Desmond A, Yildirim M, ... Ellisen LW.
Science Advances. 2020 Jan 29;6(5):eaay2611. https://doi.org/10.1126/sciadv.aay2611
PMCID: PMC6989139