The Gray BRCA Pre-Cancer Atlas seeks to transform treatment and prevention for BRCA1/2 mutation-associated cancers through innovative research and new profiling methods.

ADVANCING CANCER RESEARCH

The Gray Foundation is transforming how we identify and study the earliest stages of cancer to enable treatment before the cancer spreads. The Atlas focuses on breast and ovarian cancers and the impact on these diseases of mutations in BRCA1 or BRCA2 genes, which substantially increases the hereditary risk of cancer and also impacts treatment options for spontaneous cancers.

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Meet the People Behind the Atlas

Publications & Projects

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Multimodal spatial profiling reveals immune suppression and microenvironment remodeling in fallopian tube precursors to high-grade serous ovarian carcinoma.
Kader et al 2024. Cancer Discovery
Explore Data Publication
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Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.
Williams et al. 2024. Nature Genetics
Publication
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Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer
Li et al 2024. Nature Genetics
Publication
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H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
Ferrari et al 2023. JCI Insight
Publication

News

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Understanding the earliest stages of ovarian cancer.
HMS News 2025. LinkedIn
News

Data

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Ovarian STIC Spatial Transcriptomic Data from GeoMX and Multiplex Imaging
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Ovarian Cancer with Annotation - LSP15343
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Ovarian Cancer with Annotation - LSP15327
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Single-Cell human breast atlas integrating single-cell proteomics and transcriptomics
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Single-Cell RNA Sequencing of Breast Tissues
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BRCA1-associated-9
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BRCA1-associated-8
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BRCA WT vs BRCA1 associated TNBC